Godstones are one type of enhancement, and they can be added to an item. However, they are limited to weapons. Once they are applied to a weapon, the ability available to affect an enemy in a variety of ways is depending on the Godstone used.
Adding a Godstone to a weapon can be done successfully only when one visit the Godstone vendor in Sanctum or Pandeamonium. Drag the weapon which a player wants to enhance into the Godstone Socket Target slot, and then drag the Godstone you wish to apply into the Godstone Socket Info slot. After this, he can see the description of the effort and the cost for doing that.